Heng-Chi Lee

This study shows germ granules in C. elegans act as stress-responsive hubs that reorganize RNA granule networks to protect germ cell viability during heat stress.

This study identifies RNA Helicase A as a regulator of small RNA biogenesis and sorting in C. elegans germ cells, showing its role in protecting endogenous mRNAs from silencing and maintaining fertility.

This study identifies nucleoporins and EPS-1 as factors anchoring germ granules to NPCs in C. elegans, revealing their role in balancing piRNA and RNAi pathways.

The paper develops MUTACLASH to analyze CIMs in CLASH data, revealing that CIMs are enriched at piRNA/miRNA target sites and suggest flexible conformations of PRG-1 for target recognition.

The paper identifies that C. elegans piRNAs preferentially bind to coding regions of mRNAs, leading to secondary silencing small RNAs, and shows CSR-1 inhibits this process through two mechanisms.