Author

Jordan S. Brown

University of ChicagoORCID 0000-0001-9880-4784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Heng-Chi LeeiD· 4 shared Donglei ZhangiD· 3 shared Dong-En Lee· 2 shared Olivia J. GaylordiD· 2 shared Wei-Sheng WuiD· 2 shared Chi-Jung Chung· 1 shared Shang-Yi Lu· 1 shared Sheng-Cian Shiue· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenetics

Heng-Chi LeeORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintMay 11, 2025

RNA Helicase A promotes small RNA biogenesis and sorting in germ cells

Olivia J. Gaylord, Jordan S. Brown, Wei-Sheng Wu, Heng-Chi Lee

This study identifies RNA Helicase A as a regulator of small RNA biogenesis and sorting in C. elegans germ cells, showing its role in protecting endogenous mRNAs from silencing and maintaining fertility.

DOI 10.1101/2025.05.11.653140

C. elegansexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintFeb 14, 2025

Analysis of crosslinking sites suggests C. elegnas PIWI Argonaute exhibits flexible conformations for target recognition

Wei Wu, Dong-En Lee, Chi-Jung Chung…·Heng-Chi Lee

The paper develops MUTACLASH to analyze CIMs in CLASH data, revealing that CIMs are enriched at piRNA/miRNA target sites and suggest flexible conformations of PRG-1 for target recognition.

1 citation

C. elegansChIP-seq

𝕏 PostBluesky

GeneticsGeneticsPeer-reviewedMay 20, 2023

Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing

Jordan S. Brown, Donglei Zhang, Olivia J. Gaylord…·Heng-Chi Lee

9 citations

C. elegansexperimental assay

𝕏 PostBluesky

GenomicsbioRxivPreprintJun 8, 2022

Transcriptome-wide analysis suggests piRNAs preferentially recognize the coding region of mRNAs in C. elegans

Wei-Sheng Wu, Jordan S. Brown, Sheng-Cian Shiue…·Heng-Chi Lee

The paper identifies that C. elegans piRNAs preferentially bind to coding regions of mRNAs, leading to secondary silencing small RNAs, and shows CSR-1 inhibits this process through two mechanisms.

2 citations

C. elegansbulk RNA-seq

𝕏 PostBluesky