Positive Selection Screen Identifies Natural Product β-Catenin Inactivators
Matthew W. Boudreau, Vítor F. Freire, Sophie C. Corbett, Lucero Martínez-Fructuoso, Shilpa R. Shenoy, Wenyu Yu, Rohitesh Kumar, Christopher C. Thornburg, Rhone K. Akee, Brian D. Peyser, Qinqin Jiang, Jennifer Splaine, Jamie L. Pfaff, Dongli Yu, Benjamin C. Chandler, , William G. Kaelin
The paper screens natural products to identify β-catenin inactivators, finding one that activates novel PKCs and relocates β-catenin to juxtamembrane vacuolar structures.
Proceedings of the National Academy of Sciences · Sep 25, 2026Peer-reviewedCancer Biology