Pre-Analytical Drivers of Bias in Bead-Enriched Plasma Proteomics
Kathrin Korff, Johannes Müller, Dorothea Fichtl, Vincent Albrecht, Alicia-Sophie Schebesta, Ericka C M Itang, Sebastian Virreira Winter, Lesca Miriam Holdt, Daniel Teupser, Matthias Mann, Philipp Emanuel Geyer
This study evaluates bead-based and conventional plasma proteomics workflows, finding bead methods enhance low-abundance protein detection but are prone to contamination bias, while perchloric acid-based methods resist contamination better.
EMBO Molecular Medicine · Sep 12, 2025Peer-reviewedBiochemistry