Lesca Miriam Holdt

The paper develops patient-derived AML PDX models that replicate primary AML biology and include subgroups lacking existing models, showing reduced leukemia growth after long-term chemotherapy.

This study evaluates bead-based and conventional plasma proteomics workflows, finding bead methods enhance low-abundance protein detection but are prone to contamination bias, while perchloric acid-based methods resist contamination better.

This study identifies sequential defects in cardiac lineage commitment and maturation in hypoplastic left heart syndrome using multi-omics approaches and iPSC modeling.