ImmunologybioRxivPreprint
Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes
William A. Comrie, M. Cecilia Poli, Sarah A. Cook…·Michael J. Lenardo
Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.
DOI 10.1101/692004