Single-molecule nanophotonic resolution of binding dynamics from apo to fully liganded for a cyclic nucleotide-gated ion channel in cell-derived vesicles
Tapas Haldar, Draegan Watson, Cecilia M. Borghese, Zaid Ahmed, Perla Arianna Peña Palomino, Susanne Ressl, Audrey C. Brumback, Marcel P Goldschen-Ohm
The paper uses nanophotonic methods to observe sequential ligand binding to a cyclic nucleotide-gated ion channel at single-molecule resolution, revealing cooperative binding and intermediate states.
bioRxiv · May 27, 2026 · PreprintBiophysics