PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey N. Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, , Matthew Joseph Schiewer
This study examines how PARP inhibitors affect transcriptional responses in prostate cancer patients of different racial backgrounds, finding race-based differences in PARP1 expression and distinct transcriptional programs for each inhibitor.
Molecular Oncology · Sep 7, 2025Peer-reviewedCancer Biology