Hailey N. Shankle

Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behavior

The paper identifies lung cancer-specific p53 mutants that bind genomic sites but fail to activate transcription, revealing a novel loss-of-function mechanism in lung cancer.

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer

This study examines how PARP inhibitors affect transcriptional responses in prostate cancer patients of different racial backgrounds, finding race-based differences in PARP1 expression and distinct transcriptional programs for each inhibitor.