A matrikine organizes the dendritic cell- T cell triads that build tertiary lymphoid structures
Daniel J. Lagal, Duncan Hong, Athanasios Papadas, George Yacu, Emma Geatches, Nicholas Leschinsky, Yun Huang, Yaling Dou, Matteo Fields, Alicia Gibbons, Elsa Molina, Kersi N. Pestonjamasp, Péter T. Tóth, Alexander Cicala, João I. Mamede, , Fotis A. Asimakopoulos
This study identifies versikine, a matrikine derived from VCAN proteolysis, as essential for organizing dendritic cell-T cell triads in tertiary lymphoid structures and enhancing antitumor immunity.
bioRxiv · Oct 29, 2026 · PreprintImmunology