Author

George Yacu

Lurie Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Developmental Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:trajectory inference· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Gal FineriD· 2 shared Maria Luisa S. Sequeira-LόpeziD· 2 shared R. Ariel GomeziD· 2 shared Susan E. QuagginiD· 2 shared Alexander CicalaiD· 1 shared Alexandre G. MartiniiD· 1 shared Alicia GibbonsiD· 1 shared Athanasios PapadasiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersDevelopmental Biology

Gal FinerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A matrikine organizes the dendritic cell- T cell triads that build tertiary lymphoid structures

Daniel J. Lagal, Duncan Hong, Athanasios Papadas, George Yacu, Emma Geatches, Nicholas Leschinsky, Yun Huang, Yaling Dou, Matteo Fields, Alicia Gibbons, Elsa Molina, Kersi N. Pestonjamasp, Péter T. Tóth, Alexander Cicala, João I. Mamede, , Fotis A. Asimakopoulos

This study identifies versikine, a matrikine derived from VCAN proteolysis, as essential for organizing dendritic cell-T cell triads in tertiary lymphoid structures and enhancing antitumor immunity.

bioRxiv · Oct 29, 2026 · PreprintImmunology

The transcription factor TCF21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development

Gal Finer, George Yacu, Mohammad Daud Khan, Yalu Zhou, Gaurav T. Gadhvi, Sarah E. Ward, Mohammed E. Sayed, R. Ariel Gomez, Maria Luisa S. Sequeira-Lόpez, Joo-Seop Park, Hee‐Woong Lim, Susan E. Quaggin, Deborah R. Winter

This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.

American Journal of Physiology-Renal Physiology · Feb 3, 2026Peer-reviewedDevelopmental Biology

Tcf21 as a Founder Transcription Factor in Specifying Foxd1 Cells to the Juxtaglomerular Cell Lineage

Hina Anjum, Jason P. Smith, Alexandre G. Martini, George Yacu, Silvia Medrano, R. Ariel Gómez, Maria Luisa S. Sequeira-Lόpez, Susan E. Quaggin, Gal Finer

This study identifies Tcf21 as essential for Foxd1+ progenitor cells to differentiate into juxtaglomerular cells during kidney development, showing reduced renin expression and altered renal morphology when Tcf21 is inactivated.

American Journal of Physiology-Renal Physiology · Dec 20, 2024Peer-reviewedDevelopmental Biology