João I. Mamede

A matrikine organizes the dendritic cell- T cell triads that build tertiary lymphoid structures

This study identifies versikine, a matrikine derived from VCAN proteolysis, as essential for organizing dendritic cell-T cell triads in tertiary lymphoid structures and enhancing antitumor immunity.

Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy

The paper introduces SReD, an unsupervised framework for detecting repetitive biological structures in microscopy images, demonstrating its use on three datasets.

HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoids.

This study develops microglia-containing cerebral organoids (CO-iMs) to model HIV-1 infection and its effects on neuroinflammation and neuronal function.

An HIV-1 Reference Epitranscriptome

The paper establishes a reference HIV-1 epitranscriptome by sequencing the NL4-3 HIV-1 genome and identifying RNA modifications, revealing their stability under treatment and conservation in patients.

Recognition of HIV-1 capsid licenses innate immune response to viral infection

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.