Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1α axis
Sashaina E. Fanibunda, Sukrita Deb, Babukrishna Maniyadath, Praachi Tiwari, Utkarsha Ghai, Samir Gupta, Dwight Figueiredo, Noelia Weisstaub, Jay A. Gingrich, Ashok D. B. Vaidya, Ullas Kolthur‐Seetharam, Vidita A. Vaidya
This study identifies serotonin as a regulator of mitochondrial biogenesis and function in rodent cortical neurons through the 5-HT2A receptor and SIRT1-PGC-1α axis, with neuroprotective effects.
Proceedings of the National Academy of Sciences · May 9, 2019Peer-reviewedNeuroscience