Ullas Kolthur‐Seetharam

This study performs a cross-species RNA-seq meta-analysis to identify conserved and novel gene expression changes associated with Sirt6 perturbation in mammals and Drosophila.

This study identifies IP6K1 as a regulator of mitochondrial polyP synthesis and function, showing its role in energy homeostasis through 5-InsP7 production and a catalytic-independent mechanism.

The paper identifies the SIRT1 IDR as a temporal gate for sequential TF recruitment during fasting, showing its role in metabolic adaptation.

This study identifies diurnal variation in mitochondrial function as a key determinant of time-of-day-dependent exercise capacity in skeletal muscle.

This study shows that chronic sucrose water consumption in mice rewires tissue-specific molecular mechanisms, leading to systemic metabolic dysfunction including impaired glucose homeostasis and mitochondrial dysfunction.

The paper identifies ABHD6 as a lyso-PS lipase in the liver and kidneys, validating its enzymatic activity in vitro and in vivo.

This study shows that HIRA de-/acetylation regulates H3.3 deposition or recycling, affecting transcriptional memory and response.

The paper uses molecular dynamics simulations to show that ATP binding free energy in CDK1 is affected by acetylation at the active site and reveals non-local entropy changes linked to protein-protein interactions.

The paper identifies kinetic parameters and connectivity changes in insulin signaling that are disrupted in hyperinsulinemia.

The paper identifies kinetic parameters and connectivity changes in insulin signaling that are disrupted in hyper-insulinemic states.

This study identifies SIRT1 as essential for meiotic progression and shows it regulates repair-recombination efficiency by controlling crossover frequency and checkpoint responses.

This study identifies serotonin as a regulator of mitochondrial biogenesis and function in rodent cortical neurons through the 5-HT2A receptor and SIRT1-PGC-1α axis, with neuroprotective effects.

This study shows that Sir2 in somatic cells, specifically escort cells, regulates germline differentiation and homeostasis in Drosophila ovary through Dpp signaling and genetic interactions with upd2.

This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.