Vidita A. Vaidya

Serotonin2A receptors in the medial prefrontal cortex do not drive DOI-induced head-twitch responses in rodents

This study investigates the role of 5-HT2A receptors in the medial prefrontal cortex in DOI-induced head-twitch responses in rodents, finding no contribution from mPFC 5-HT2ARs.

Early-life stress-induced gut dysbiosis is ameliorated by nicotinamide treatment

This study shows that nicotinamide treatment reduces gut dysbiosis in middle-aged rodents with a history of neonatal maternal separation.

Chronic postnatal chemogenetic activation of forebrain excitatory neurons modulates adult glial function and metabolism in male mice

This study shows that postnatal chemogenetic activation of forebrain excitatory neurons leads to anxiety-like behaviors and altered glial function and metabolism in adult mice.

A Cell-Permeable Fluorescent Probe Reveals Temporally Diverse PI(4,5)P2 Dynamics Evoked by Distinct GPCR Agonists in Neurons

This paper develops a fluorescent probe to track PI(4,5)P2 dynamics in neurons, revealing that hallucinogenic ligands at the 5-HT2A receptor cause slower initial PI(4,5)P2 depletion compared to non-hallucinogenic ligands.

Chronic chemogenetic activation of hippocampal progenitors enhances adult neurogenesis and modulates anxiety-like behavior and fear extinction learning

This study shows that chemogenetic activation of adult hippocampal progenitors increases neurogenesis and affects anxiety-like behavior and fear extinction learning in mice.

Fluoxetine treatment during postnatal and juvenile temporal epochs evokes diametrically opposing changes in anxio-depressive behaviors, gene expression, mitochondrial function, and neuronal architecture in the medial prefrontal cortex

This study shows that fluoxetine treatment during postnatal or juvenile periods leads to opposing effects on anxiety-depressive behaviors, gene expression, mitochondrial function, and neuronal structure in adult rats.

Chronic hM3Dq-DREADD mediated chemogenetic activation of parvalbumin-positive inhibitory interneurons in postnatal life alters anxiety and despair-like behavior in adulthood in a task and sex-dependent manner

This study shows that chemogenetic activation of PV-positive interneurons during postnatal life reduces anxiety and despair-like behaviors in adulthood, with sex-dependent effects.

Genetic loss of norepinephrine does not alter adult hippocampal neurogenesis in dopamine β-hydroxylase deficient mice

The paper investigates the effect of genetic NE loss on adult hippocampal neurogenesis and finds no difference in progenitor proliferation or survival in Dbh-/- mice, contrasting with pharmacological NE depletion.

Chronic hM4Di-DREADD mediated chemogenetic inhibition of forebrain excitatory neurons in postnatal or juvenile life does not alter adult mood-related behavior

This study inhibits forebrain excitatory neurons during postnatal or juvenile stages using DREADD and finds no effect on adult mood-related behaviors or sensorimotor gating.

The hallucinogenic serotonin2A receptor agonist, DOI, promotes CREB-dependent gene expression of specific plasticity-associated genes in the rodent neocortex

This study shows that the hallucinogenic 5-HT2A agonist DOI increases CREB-dependent expression of plasticity-associated genes in the rodent neocortex.

Postnatal fluoxetine treatment alters perineuronal net formation and maintenance in the hippocampus

This study shows that postnatal fluoxetine treatment reduces perineuronal nets in specific hippocampal regions, affecting neural development and plasticity.

Chronic chemogenetic activation of forebrain excitatory neurons in postnatal life evokes long-lasting changes in mood-related behavior

This study shows that chronic chemogenetic activation of forebrain excitatory neurons during postnatal life leads to long-lasting mood-related behavioral and neurophysiological changes.

Chemogenetic activation of excitatory neurons alters hippocampal neurotransmission in a dose-dependent manner

The paper investigates how different doses of CNO affect excitatory neurotransmission in the hippocampus using hM3Dq DREADD activation in mice.

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1α axis

This study identifies serotonin as a regulator of mitochondrial biogenesis and function in rodent cortical neurons through the 5-HT2A receptor and SIRT1-PGC-1α axis, with neuroprotective effects.