Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma
Elizabeth R. Woodruff, Courtney A. Bailey, Francis To, Vyshnavi Manda, Joanne K. Maltzahn, Timothy M Sullivan, Meher P. Boorgula, María Sol Recouvreux, Ruby Vianzon, Bogdan Conrad, Kathleen M. Gavin, Kimberly Rae Jordan, Dwight J. Klemm, Sandra Oršulić, Benjamin Guy Bitler, Zachary L. Watson
This study shows that ablating hematopoietic stem cell-derived adipocytes reduces tumor burden in mouse models of high-grade serous carcinoma through metabolic and immune mechanisms.
bioRxiv · Sep 19, 2024 · PreprintCancer Biology