Benjamin Guy Bitler

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

Cross-assay RNA modeling reveals cancer biomarkers

This paper integrates multiple transcriptomics assays to identify cancer biomarkers, finding GBP4 as a predictor of recurrence and immune remodeling.

On the predictability of progression-free survival in ovarian cancer from NanoString gene expression data

This study investigates the predictability of progression-free survival in ovarian cancer using NanoString gene expression data from pre- and post-chemotherapy samples, finding low predictability and suggesting the need for larger datasets.

Transcriptomic subtypes in high-grade serous ovarian cancer are driven by tumor cellular composition

This study shows HGSC transcriptomic subtypes are driven by tumor cellular composition rather than intrinsic biology, with high predictive accuracy using deconvolution methods.

Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer model

This study identifies RAD52 as a target to overcome PARP inhibitor resistance in BRCA2-deficient ovarian cancer by showing its role in DNA repair and demonstrating synergistic effects with PARP inhibitors.

PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis.

This study shows PARP1 and PARP2 are not required for MMEJ during mitosis, challenging previous assumptions and supporting combinatorial PARPi/MMEJi therapy in HR-deficient cancers.

Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents.

This paper shows that claudin-4 remodels nucleus-cell cycle interactions to maintain genome stability and resist genomic instability-inducing agents in ovarian cancer.

Regulation of interferon signaling by transposon exonization

The paper identifies transposon exonization as a mechanism regulating interferon signaling by generating functional variants of immune genes, including a decoy receptor that inhibits interferon signaling.

Cannabidiol promotes apoptosis and downregulation of oncogenic factors

This study investigates CBD's effects on ovarian cancer cells, finding it promotes apoptosis and inhibits growth at high concentrations but has minimal impact at physiologic doses.

Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma

This study shows that ablating hematopoietic stem cell-derived adipocytes reduces tumor burden in mouse models of high-grade serous carcinoma through metabolic and immune mechanisms.

Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer

The paper identifies ERV-derived enhancers as drivers of transcriptional rewiring in colorectal cancer through oncogenic AP1/MAPK signaling.

SMASH: Scalable Method for Analyzing Spatial Heterogeneity of genes in spatial transcriptomics data

SMASH identifies spatially variable genes in spatial transcriptomics data with improved statistical power and computational efficiency.

A Platform-Independent Framework for Phenotyping of Multiplex Tissue Imaging Data

The paper introduces a platform-independent preprocessing framework for multiplex tissue imaging data to improve cross-platform consistency and reliability.

SPF: A Spatial and Functional Data Analytic Approach to cell Imaging data

The paper introduces a spatial and functional analytic approach to model the impact of tumor-stromal cell interactions on survival in cancer patients using imaging data.