Amyloid precursor protein interacts with the mitochondrial phosphatase PGAM5 and regulates mitochondrial respiration
Kriti Shukla, Z. Zhang, Kendra S. Plafker, Satoshi Matsuzaki, Casandra Salinas-Salinas, Yvonne M. Thomason, Samah Houmam, Dylan Barber, Anna Faakye, Kenneth Michael Humphries, Scott M. Plafker, Jialing Lin, Heather C. Rice
This study identifies an interaction between APP and PGAM5, showing that APP regulates mitochondrial respiration by modulating Keap1-Nrf2 signaling.
bioRxiv · Mar 12, 2026 · PreprintNeuroscience