Kenneth Michael Humphries

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function

This paper shows that loss of PFKFB2 in cardiac cells leads to electrophysiological instability, including prolonged repolarization and ventricular tachyarrhythmia, linking glycolytic regulation to heart function.

Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD

This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.

Amyloid precursor protein interacts with the mitochondrial phosphatase PGAM5 and regulates mitochondrial respiration

This study identifies an interaction between APP and PGAM5, showing that APP regulates mitochondrial respiration by modulating Keap1-Nrf2 signaling.

PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization

This study investigates the role of PFKFB2 in cardiac metabolic flexibility and glucose utilization, finding that its loss impairs mitochondrial function and affects systemic glucose homeostasis under stress.

PKC-dependent enhancement of glutamate input to VTA dopamine neurons in 3xTg-AD mice

The paper investigates synaptic input changes in VTA dopamine neurons of 3xTg-AD mice, finding enhanced excitatory input and reduced inhibition linked to PKC activity.

Multimodal Analysis of Sepsis-induced Cardiomyopathy in a Baboon Model

This study uses a baboon model of sepsis to analyze cardiomyopathy through multimodal techniques, finding distinct transcriptomic and physiological differences between survivors and non-survivors.

Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity

The paper identifies and validates a new inhibitor, B2, of PFKFB2 kinase activity through enzymatic assays and metabolic profiling in A-498 cells.