The combination of optogenetic-induced protein aggregation and proximity biotinylation assays strongly implicates endolysosomal proteins in the early stages of α-synuclein aggregation
Maxime Teixeira, Razan Sheta, Dylan Musiol, Vetso Ranjakasoa, Jérémy Loehr, Jean‐Philippe Lambert, Abid Oueslati
This paper introduces UltraID-LIPA, a platform combining optogenetic-induced protein aggregation and proximity biotinylation to identify α-synuclein-interacting proteins, revealing endolysosomal proteins' role in early aggregation.
iScience · Jun 5, 2025Peer-reviewedNeuroscience