Jérémy Loehr

Long-read RNA sequencing identifies non-coding isoform switching as a regulator of cell fate

The paper uses long-read RNA sequencing to identify non-coding isoform switching that regulates cell fate during reprogramming.

The combination of optogenetic-induced protein aggregation and proximity biotinylation assays strongly implicates endolysosomal proteins in the early stages of α-synuclein aggregation

This paper introduces UltraID-LIPA, a platform combining optogenetic-induced protein aggregation and proximity biotinylation to identify α-synuclein-interacting proteins, revealing endolysosomal proteins' role in early aggregation.

Coupling proximity biotinylation with genomic targeting to characterize locus-specific changes in chromatin environments

The paper develops and applies CasTurbo and CasUltra to profile locus-specific chromatin proteomes and study BET inhibitor effects on MYC promoter dynamics.

Systematic profiling of the acetyl lysine machinery reveals a role for MAPKAPK2 in bromodomain inhibitor resistance

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9

This paper engineers CRISPR-Cas9 variants from Streptococcus thermophilus to target diverse A-rich PAMs, enabling efficient genome editing in mice.

A marker-free co-selection strategy for high efficiency human genome engineering

This paper introduces a marker-free co-selection strategy to enhance gene editing efficiency in human cells using CRISPR-Cas9 and Cpf1 systems.