Abid Oueslati

This study uses an optogenetic system to show that phosphorylation and lipid droplets drive the irreversible phase transition of α-synuclein in cells, leading to neurotoxic aggregates linked to Parkinson's disease.

This study identifies WDR44 as a driver of de novo α-synuclein aggregation at the lysosomal membrane, linking early aggregation events to neuronal dysfunction in Parkinson's Disease.

This study uses human iPSC-derived dopaminergic neurons to model Parkinson's Lewy body pathology without genetic modification, revealing mechanisms of aSyn aggregation and morphological diversity.

This paper introduces UltraID-LIPA, a platform combining optogenetic-induced protein aggregation and proximity biotinylation to identify α-synuclein-interacting proteins, revealing endolysosomal proteins' role in early aggregation.