Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia
Yujiao Han, Hirak Sarkar, Zhan Xu, Sereno L. Lopez-Darwin, Yong Xu Wei, Xiang Hang, Fengshuo Liu, Kimberley Tran, Wei Wang, Jennifer M. Miller, Christina J. DeCoste, Dylan S. Blohm, Robert L. Satcher, Xiang H.-F. Zhang, Yibin Kang
The paper identifies iron-recycling macrophages in bone metastases that support tumor growth and anemia by hijacking erythropoiesis and enabling tumor cell erythroblast mimicry.
bioRxiv · Apr 23, 2025 · PreprintCancer Biology