Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.
Fengshuo Liu, Yunfeng Ding, Zhan Xu, Xiaoxin Hao, Tianhong Pan, George E. Miles, Siyue Wang, Yi-Hsuan Wu, Jun Liu, I. L. Bado, Weijie Zhang, Ling Wu, Yang Gao, Liqun Yu, David G. Edwards, , Xiang H.-F. Zhang
The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.
Cell Genomics · May 23, 2025Peer-reviewedCancer Biology