Xiang H.-F. Zhang

This study identifies an early neutrophil interferon program that predicts resistance to anti-PD1 therapy and limits durable anti-tumor immunity.

This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

The paper shows that combining anti-CSF-1R therapy with chemotherapy and anti-PD-1 improves immune response in metastatic TNBC by reducing macrophages and increasing T/B cell infiltration.

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

The paper identifies iron-recycling macrophages in bone metastases that support tumor growth and anemia by hijacking erythropoiesis and enabling tumor cell erythroblast mimicry.

The paper shows MAGE-A4 promotes NSCLC by recruiting IgA+ plasma cells, reducing tumor burden and enhancing T cell activity.

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

MUSTANG performs multi-sample spatial transcriptomics analysis by integrating cross-sample similarity and spatial correlation to improve cellular deconvolution.

This paper introduces ReSort, a method to improve cell type deconvolution in spatial transcriptomics by reducing batch effects, and shows it enhances accuracy in mouse breast cancer data.

This work evaluates CRISPR lineage recorders using TraceQC to analyze mutation speed and distribution across platforms.