Sereno L. Lopez-Darwin

Engaging the host adaptive response to nutrient limitation delays cancer cachexia

This study shows that caloric restriction before tumor induction delays cancer cachexia by reducing systemic inflammation and preserving lean mass.

Behavioral dysfunction but not wasting in cancer cachexia is driven by altered tryptophan metabolism

The paper identifies altered tryptophan metabolism in cancer cachexia, showing serotonin depletion and kynurenine accumulation, which drive behavioral dysfunction but not wasting.

Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia

The paper identifies iron-recycling macrophages in bone metastases that support tumor growth and anemia by hijacking erythropoiesis and enabling tumor cell erythroblast mimicry.

Mapping the topography of spatial gene expression with interpretable deep learning

This paper introduces GASTON, an interpretable deep learning method to map spatial gene expression topography, identifying gradients and domains in spatial transcriptomics data.

The landscape of alternative polyadenylation in single cells of the developing mouse embryo

The paper quantifies alternative polyadenylation (APA) across 2 million single cells from developing mouse embryos, revealing dynamic changes in 3' UTR length and identifying potential regulators in neuronal and hematopoietic lineages.