Mitochondrial mass governs the extent of T cell senescence
L. A. Callender, E. C. Carroll, E. A. Bober, A. N. Akbar, E. Solito, S. M. Henson
This study shows that mitochondrial mass differences between CD4+ and CD8+ T cells drive their distinct susceptibility to senescence, with reduced mitochondrial function inducing a CD8+ -like phenotype in CD4+ T cells.
bioRxiv · May 4, 2019Immunology