Author

A. N. Akbar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. C. Carroll· 2 shared L. A. Callender· 2 shared S. M. Henson· 2 shared A. Kelly· 1 shared B. B. Shih· 1 shared D. Gilroy· 1 shared E. A. Bober· 1 shared E. Hendy· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

E. C. Carroll

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3 papers

Recent·Most cited

GATA3 controls mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

L. A. Callender, J. Schroth, E. C. Carroll, L. E. L. Romano, E. Hendy, A. Kelly, P. Lavender, A. N. Akbar, J. P. Chapple, S. M. Henson

This study identifies a novel mechanism by which GATA3 regulates mitochondrial biogenesis in primary human CD4+ T cells in response to DNA damage.

bioRxiv · May 15, 2020 · PreprintImmunology

Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing

E. S. Chambers, M. Vukmanovic-Stejic, B. B. Shih, H. Trahir, P. Subramanian, O. P. Devine, J. Glanville, D. Gilroy, M. Rustin, T. C. Freeman, N. A. Mabbott, A. N. Akbar

This study shows that inflammation from tissue injury in older adults reduces cutaneous immunity to VZV by recruiting monocytes that produce PGE2, which can be reversed with a p38-MAPK inhibitor.

bioRxiv · Apr 2, 2020Immunology

Mitochondrial mass governs the extent of T cell senescence

L. A. Callender, E. C. Carroll, E. A. Bober, A. N. Akbar, E. Solito, S. M. Henson

This study shows that mitochondrial mass differences between CD4+ and CD8+ T cells drive their distinct susceptibility to senescence, with reduced mitochondrial function inducing a CD8+ -like phenotype in CD4+ T cells.

bioRxiv · May 4, 2019Immunology