Author

E. A. Goncharova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. Piper· 2 shared D. Goncharov· 2 shared G. Newcomb· 2 shared L. Farkas· 2 shared S. Bogamuwa· 2 shared T. V. Kudryashova· 2 shared A. Alsuraimi· 1 shared A. B. Waxman· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

B. Piper

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

B. Piper, S. Bogamuwa, T. Hossain, D. Farkas, L. Rosas, A. Green, G. Newcomb, N. Sun, J. C. Horowitz, A. R. Bhagwani, H. Yang, T. V. Kudryashova, M. Rojas, A. L. Mora, P. Yan, , L. Farkas

This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.

Journal of Clinical Investigation · Feb 1, 2024Peer-reviewedPhysiology

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension

T. V. Kudryashova, S. V. Zaitsev, L. Jiang, B. J. Buckley, J. P. McGuckin, D. Goncharov, I. Zhyvylo, D. Lin, G. Newcomb, B. Piper, S. Bogamuwa, A. Saiyed, L. Teos, M. Ranson, P. Wolters, , V. Stepanova

This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.

bioRxiv · Sep 21, 2023Cell Biology

The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension

A. Gorelova, M. Berman, M. Sharifi-Sanjani, A. Pulgarin Rocha, A. Alsuraimi, P. Riva, V. Negi, T. Bertero, D. Goncharov, T. Kudryashova, A. Dosunmu-Ogunbi, A. Rajaratnam, L. Harvey, M. Nouraie, J. Baust, , I. Al Ghouleh

This study shows EBP50 downregulation promotes EndMT in pulmonary hypertension by increasing Snail, Zeb1, and Slug expression, and mesenchymal markers, while reducing cell proliferation and barrier function.

bioRxiv · May 31, 2022 · PreprintCell Biology

Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties

D. Sharifi Kia, Y. Shen, T. N. Bachman, E. A. Goncharova, K. Kim, M. A. Simon

This study examines how healthy aging affects right ventricular structure and biomechanical properties in rats, finding increased peak pressures, wall thickness, and fiber reorientation.

bioRxiv · Sep 8, 2020 · PreprintBioengineering