M. S. Kim

A GWAS-machine learning framework reveals protein-synthesis pathway signals for yield in Theobroma cacao after population-structure correction

This study uses a GWAS and machine learning framework to identify genetic signals related to protein-synthesis pathways that influence cacao yield after correcting for population structure.

Taxonomy-agnostic hyperspectral-morphological phenotyping of fungal pathogen chemical-stress responses using machine learning

This paper develops a taxonomy-agnostic workflow using hyperspectral imaging and machine learning to predict fungal isolate crop-source labels with 86.7% accuracy.

The role of positively charged small biomolecules in the aggregation of hyperphosphorylated tau in Alzheimer's disease

This study identifies electrostatic interactions between hyperphosphorylated tau and polyamines as crucial for tau aggregation in Alzheimer's disease and observes the transition from aggregates to fibrils.

Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

Gli2 and Gli3 Regulate Horizontal Basal Cell-Mediated Regeneration of the Olfactory Epithelium

This study shows GLI2 and GLI3 regulate HBC-mediated olfactory epithelium regeneration by controlling proliferation, identity, and differentiation of HBCs following injury.

Kinetic Characterization and Computational Modeling of the Escherichia coli Heptosyltransferase II: Exploring the Role of Protein Dynamics in Catalysis for a GT-B Glycosyltransferase

This paper characterizes the kinetic and biophysical properties of Escherichia coli HepII, a GT-B glycosyltransferase, and develops a structural model to understand its catalytic mechanism and substrate interactions.

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade

The paper identifies plasma proteomic biomarkers that predict non-response to PD1 blockade in melanoma patients and links them to tumor microenvironment biology.

Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies

The paper uses patient-derived iPS cells to model liver pathologies in telomeropathies and identifies AKT suppression as a potential therapeutic target.

Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

Metabolic and Proteomic Defects in Human Hypertrophic Cardiomyopathy

This study identifies metabolic and proteomic defects in human hypertrophic cardiomyopathy, showing depletion of fatty acid derivatives and increased alternate fuel metabolites.

β-adrenergic stimulation synchronizes a broad spectrum of action potential firing rates of cardiac pacemaker cells towards a higher population average

The study shows that β-adrenergic stimulation causes SAN cells to synchronize their firing rates towards a higher average, rather than uniformly increasing each cell's rate.

Stable Isotope Tracing In Vivo Reveals A Metabolic Bridge Linking The Microbiota To Host Histone Acetylation

This study uses stable isotope tracing to show that gut microbiota supply carbon for host histone acetylation, linking microbial metabolism to host epigenetic regulation.

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

This paper demonstrates the formation of lymphoid follicles in a human organ-on-a-chip model and shows improved vaccine responses compared to 2D cultures.

Distinct function of Mediator subunits in fungal development, stress response and secondary metabolism in fungal pathogen Fusarium verticillioides

This study investigates the functions of Mediator subunits in Fusarium verticillioides, showing that some subunits have unique regulatory roles in development, stress response, and secondary metabolism.

Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastoma

This study identifies Endocan as an endothelial-secreted ligand for PDGFR alpha that promotes GBM vascularity, radioresistance, and phenotypic diversity.

The instantaneous multi-pronged defense system of latex against general plant enemies

The paper investigates metabolic variation in latex of Euphorbia species to understand its role in plant defense against pathogens and other enemies.

FvLcp1, a type-D fungal LysM protein with Chitin-binding domains, is a secreted protein involved in host recognition and fumonisin production in Fusarium verticillioides - maize kernel interaction

This paper identifies FvLcp1, a secreted type-D fungal LysM protein with chitin-binding domains, as a key factor in fumonisin production and host recognition in F. verticillioides during maize infection.

Revised subunit order of mammalian septin complexes explains their in vitro polymerization properties

The paper revises the subunit order of mammalian septin complexes, showing they can co-polymerize and revealing an inverted organization compared to previous predictions.

Characterizing co-expression networks underpinning maize stalk rot virulence in Fusarium verticillioides through computational subnetwork module analyses

The paper identifies virulence-related subnetwork modules in Fusarium verticillioides using co-expression analysis and predicts maize genes responding to fungal virulence factors.