Author

E. C. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Animal Behavior & Cognition· 1 Biochemistry· 1

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Research Focus:chromatin & epigenetic regulation· 4 Organism:Drosophila· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Research Focus:clustering· 2 Research Focus:development & morphogenesis· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

J. Vedanayagam· 3 shared C.-J. Lin· 2 shared A. Claridge-Chang· 1 shared A. Garg· 1 shared A. S. Flynt· 1 shared B. Joseph· 1 shared B. Y. Kim· 1 shared C. Dai· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersEvolutionary Biology

J. Vedanayagam

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5 papers

Recent·Most cited

The structural landscape of Microprocessor Mediated pri-let-7 miRNA processing

A. Garg, R. Shang, T. Cvetanovic, E. C. Lai, L. Joshua-Tor

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.

bioRxiv · May 9, 2024 · PreprintBiochemistry

Rapid evolutionary diversification of the flamenco locus in the D. simulans clade

S. Signor, J. Vedanayagam, B. Y. Kim, F. Wierzbicki, R. Kofler, E. C. Lai

The paper examines the rapid evolutionary changes in the flamenco locus across Drosophila simulans clade species, revealing sequence divergence, copy number variation, and functional adaptations related to transposable element suppression.

bioRxiv · Sep 29, 2022 · PreprintEvolutionary Biology

Endogenous RNAi silences a burgeoning sex chromosome arms race

J. Vedanayagam, C.-J. Lin, R. Papareddy, M. D. Nodine, A. S. Flynt, J. Wen, E. C. Lai

This study shows endogenous RNAi suppresses X-linked meiotic drive loci in Drosophila simulans, revealing rapid evolution of hpRNA-target interactions and their role in sex chromosome conflict.

bioRxiv · Aug 22, 2022 · PreprintEvolutionary Biology

Red queen's race: rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors

J. Vedanayagam, C.-J. Lin, E. C. Lai

The paper traces the evolutionary dynamics of meiotic drive factors and their hpRNA suppressors in Drosophila species, revealing rapid gene amplification and genomic conflicts.

bioRxiv · Aug 5, 2021Evolutionary Biology

A neural m6A/YTHDF pathway is required for learning and memory in Drosophila

L. Kan, S. Ott, B. Joseph, E. S. Park, C. Dai, R. Kleiner, A. Claridge-Chang, E. C. Lai

This study identifies the m6A/YTHDF pathway's role in learning and memory in Drosophila by mapping m6A sites and showing their impact on translation and neural function.

bioRxiv · Mar 7, 2020Animal Behavior & Cognition