Author

L. Joshua-Tor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1

Frequent Co-Authors

D. R. Thomas· 3 shared A. Axhemi· 1 shared A. Doymaz· 1 shared A. G. Palmer· 1 shared B. Bibel· 1 shared B. Stillman· 1 shared C. W. Diehnelt· 1 shared E. A. Komives· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersBiochemistry

D. R. Thomas

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Author profile →

5 papers

Recent·Most cited

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

B. Bibel, E. Elkayam, S. Silletti, E. A. Komives, L. Joshua-Tor

The paper shows that miRNA-loaded Ago2 binding to target RNA primes its EI for CK1-mediated phosphorylation, which facilitates target release through electrostatic effects.

bioRxiv · Jan 6, 2022Biochemistry

A shape-shifting nuclease unravels structured RNA

K. Meze, A. Axhemi, D. R. Thomas, A. Doymaz, L. Joshua-Tor

The paper characterizes the degradation mechanism of Dis3L2 by analyzing its conformational changes during structured RNA processing.

bioRxiv · Nov 30, 2021Biochemistry

The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures

M. J. Jaremko, K. F. On, D. R. Thomas, B. Stillman, L. Joshua-Tor

The paper reports five cryoEM structures of the human ORC, revealing its dynamic conformations and DNA-binding mechanisms.

bioRxiv · Aug 13, 2020Biochemistry

Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons

J. J. Ipsaro, P. A. O'Brien, S. Bhattacharya, A. G. Palmer, L. Joshua-Tor

This study shows Asterix/Gtsf1 binds tRNAs and is essential for piRNA-mediated silencing of LTR retrotransposons.

bioRxiv · Aug 11, 2020Biochemistry

High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations

J. Jung, T. Grant, D. R. Thomas, C. W. Diehnelt, N. Grigorieff, L. Joshua-Tor

The paper presents high-resolution cryo-EM structures of multiple human norovirus strains, revealing size variations and structural polymorphism.

bioRxiv · Mar 16, 2019Biophysics