Rapid macropinocytic transfer of α-synuclein to lysosomes
A. Bayati, E. Banks, C. Han, W. Luo, W. E. Reintsch, C. E. Zorca, I. Shlaifer, E. D. C. Pellitero, B. Vanderperre, H. M. McBride, E. A. Fon, T. A. Durcan, P. S. McPherson
This study shows alpha-synuclein fibrils are rapidly internalized via macropinocytosis and directed to lysosomes, with some transferred to neighboring cells.
bioRxiv · Jan 6, 2022Cell Biology