Author

I. Shlaifer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

E. A. Fon· 3 shared W. Luo· 3 shared B. Vanderperre· 2 shared C. X.- Q. Chen· 2 shared M.-F. Dorion· 2 shared P. S. McPherson· 2 shared T. Durcan· 2 shared W. E. Reintsch· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

E. A. Fon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia

M.-F. Dorion, K. Senkevich, M. Yaqubi, N. W. Kieran, C. X.- Q. Chen, A. MacDonald, W. Luo, A. Wallis, I. Shlaifer, J. Hall, R. W. R. Dudley, I. A. Glass, Birth Defects Research Laboratory, J. A. Straton, E. A. Fon, , L. M. Healy

This study shows MerTK mediates microglial uptake of alpha-synuclein fibrils without triggering inflammation and links MERTK variants to Parkinson's disease.

bioRxiv · Mar 4, 2023 · PreprintCell Biology

The identification of potent and selective antibodies for Serine/threonine-protein kinase TBK1, for use in immunoblot, immunofluorescence and immunoprecipitation

W. Alshafie, M. Fotouhi, I. Shlaifer, A. Edwards, T. Durcan, P. S. McPherson, C. Laflamme

The paper evaluates 11 commercial antibodies for TBK1 detection in immunoblot, immunofluorescence, and immunoprecipitation using a knock-out cell line to identify potent and selective antibodies.

bioRxiv · Jun 3, 2022 · PreprintBiochemistry

Rapid macropinocytic transfer of α-synuclein to lysosomes

A. Bayati, E. Banks, C. Han, W. Luo, W. E. Reintsch, C. E. Zorca, I. Shlaifer, E. D. C. Pellitero, B. Vanderperre, H. M. McBride, E. A. Fon, T. A. Durcan, P. S. McPherson

This study shows alpha-synuclein fibrils are rapidly internalized via macropinocytosis and directed to lysosomes, with some transferred to neighboring cells.

bioRxiv · Jan 6, 2022Cell Biology