Author

H. M. McBride

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:metabolomics· 2

Frequent Co-Authors

M. Nguyen· 3 shared M. Desjardins· 2 shared O. Ignatenko· 2 shared A. Bayati· 1 shared A. Besse-Patin· 1 shared A. G. Hendricks· 1 shared A. Kazanova· 1 shared A. MacDonald· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

M. Nguyen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment

E. N. P. Prowse, B. A. Turkalj, M. Sebastien, D. Beaudet, H. M. McBride, G. J. Brouhard, M. A. Pouladi, A. G. Hendricks

This study shows that HTT polyQ expansions disrupt motor and adaptor recruitment to vesicles, causing transport defects and altered responses to neuroinflammatory stress.

bioRxiv · Apr 12, 2024Cell Biology

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

A. Kazanova, J. Sung, N. L. Oliveira, C. Gavino, H. Bessaiah, J. Pei, L. Burns, W. Miller, M. Brouillard-Galipeau, L. Zhu, L. M. Guerra, M. N. Elemeery, S. J. Recinto, A. MacDonald, J. Lanoix, , S. Gruenheid

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

bioRxiv · Feb 25, 2024 · PreprintImmunology

Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

M. Nguyen, J. J. Collier, O. Ignatenko, G. Morin, S. Huang, M. Desjardins, H. M. McBride

The paper identifies a pyroptotic pathway involving Parkinson's disease proteins and mtDNA trafficking to lysosomes.

bioRxiv · Sep 11, 2023 · PreprintCell Biology

Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.

A. Yamashita, O. Ignatenko, M. Nguyen, R. Lambert, K. Watt, C. Daneault, I. Robillard-Frayne, I. Topisirovic, C. Des Rosiers, H. M. McBride

The paper investigates the effects of LONP2 depletion on peroxisomal function and cholesterol metabolism, revealing cell-type-specific responses and implications for peroxisomal disorders.

bioRxiv · Mar 15, 2023Cell Biology

SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

V. Goyon, A. Besse-Patin, R. Zunino, M. Nguyen, E. Coyaud, J. M. Lee, B. N. Nguyen, B. Raught, H. M. McBride

This study identifies MAPL's role in regulating bile acid synthesis and metabolic homeostasis, showing its loss leads to insulin sensitivity and hepatocellular carcinoma.

bioRxiv · Mar 3, 2022 · PreprintCell Biology

Rapid macropinocytic transfer of α-synuclein to lysosomes

A. Bayati, E. Banks, C. Han, W. Luo, W. E. Reintsch, C. E. Zorca, I. Shlaifer, E. D. C. Pellitero, B. Vanderperre, H. M. McBride, E. A. Fon, T. A. Durcan, P. S. McPherson

This study shows alpha-synuclein fibrils are rapidly internalized via macropinocytosis and directed to lysosomes, with some transferred to neighboring cells.

bioRxiv · Jan 6, 2022Cell Biology