ImmunologybioRxiv
NAIP-NLRC4 Inflammasome Activation in Tuft Cells Activates a PGD2-ILC3 Signaling Circuit that Protects Against Enteric Infection.
M. J. Churchill, R. Bauer, R. Honodel…·I. Rauch
This study shows that NAIP-NLRC4 inflammasome activation in tuft cells releases PGD2, which signals to ILC3s to enhance antibacterial defenses against Salmonella Typhimurium.
DOI 10.1084/jem.20230803