Author

I. Rauch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. E. Vance· 3 shared K. A. Deets· 2 shared R. A. Chavez· 2 shared R. Bauer· 2 shared A. Jain· 1 shared A. P. Wright· 1 shared A. R. Gibson· 1 shared A. Y. Lee· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersImmunology

R. E. Vance

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Interferon Regulatory Factor 6 Determines Intestinal Epithelial Cell Development and Immunity

A. P. Wright, S. Harris, S. R. Madden, B. Ramirez Reyes, E. Mulamula, A. R. Gibson, I. Rauch, D. A. Constant, T. J. Nice

This study identifies IRF6's role in regulating intestinal epithelial cell development and innate immunity, showing it modulates antiviral responses and maintains barrier function.

bioRxiv · Jan 4, 2024Immunology

NAIP-NLRC4 Inflammasome Activation in Tuft Cells Activates a PGD2-ILC3 Signaling Circuit that Protects Against Enteric Infection.

M. J. Churchill, R. Bauer, R. Honodel, T. Christopher, S. Smita, L. Warner, B. M. Mooney, E. D. T. Wojno, I. Rauch

This study shows that NAIP-NLRC4 inflammasome activation in tuft cells releases PGD2, which signals to ILC3s to enhance antibacterial defenses against Salmonella Typhimurium.

bioRxiv · May 11, 2023Immunology

Salmonella Typhimurium induces NAIP/NLRC4- and NLRP3/ASC-independent, caspase-1/4-dependent inflammasome activation in human intestinal epithelial cells

N. Naseer, R. Bauer, J. Zhang, I. E. Brodsky, I. Rauch, S. Shin

This study shows that human intestinal epithelial cells use caspase-1/4-dependent inflammasomes, not NAIP/NLRC4 or NLRP3/ASC, to respond to Salmonella Typhimurium.

bioRxiv · Dec 9, 2021 · PreprintMicrobiology

Pyroptosis-dependent and -independent cross-priming of CD8+ T cells by intestinal epithelial cell-derived antigen

K. A. Deets, R. D. Nichols, I. Rauch, R. E. Vance

The paper shows that IEC-derived antigens can cross-prime CD8+ T cells through both pyroptosis-dependent and -independent pathways involving cDC1.

bioRxiv · Jul 8, 2021Immunology

NAIP-NLRC4-deficient mice are susceptible to shigellosis

P. S. Mitchell, J. L. Roncaioli, E. A. Turcotte, L. Goers, R. A. Chavez, A. Y. Lee, C. F. Lesser, I. Rauch, R. E. Vance

This study shows that NAIP-NLRC4-deficient mice are susceptible to Shigella infection, mimicking human shigellosis, and reveals that inflammasome-mediated cell death protects against the disease.

bioRxiv · May 16, 2020Microbiology

New mutant mouse models clarify the role of NAIPs, phosphorylation, NLRP3, and tumors in NLRC4 inflammasome activation

J. Tenthorey, R. A. Chavez, T. W. Thompson, K. A. Deets, R. E. Vance, I. Rauch

This study uses genetic models to show that NLRC4 phosphorylation and NLRP3 do not play a role in NAIP/NLRC4 inflammasome activation or anti-tumor responses.

bioRxiv · Sep 18, 2019Immunology

Transcriptome profiling of pathogen-specific CD4 T cells identifies T-cell-intrinsic caspase-1 as an important regulator of Th17 differentiation

Y. Gao, K. Deason, A. Jain, R. A. Irizarry-Caro, I. Dozmorov, I. Rauch, E. K. Wakeland, C. Pasare

bioRxiv · Oct 25, 2018Immunology