Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially-infected epithelial cells
E. E. Bastounis, F. S. Alcade, P. Radhakrishnan, P. Engstrom, M. J. Gomez Benito, M. S. Oswald, J. G. Smith, M. Welch, J. M. Garcia-Aznar, J. A. Theriot
The paper shows that innate immune signaling triggers mechanical competition, leading to the collective extrusion of infected epithelial cells by uninfected bystanders.
bioRxiv · Jan 22, 2020Microbiology