J. M. Garcia-Aznar

PhysiCOOL: A generalized framework for model Calibration and Optimization Of modeLing projects

PhysiCOOL provides an open-source Python library for calibrating and optimizing PhysiCell models without requiring high-performance computing.

Tumour growth: Bayesian parameter calibration of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment

This study calibrates a porous media model of neuroblastoma spheroid growth using Bayesian methods and in vitro experiments to infer mechanical properties.

Modeling the three-way feedback between cellular contractility, actin polymerization, and adhesion turnover resolves the contradictory effects of RhoA and Rac1 on endothelial junction dynamics

This study develops a chemo-mechanical model to explain how RhoA and Rac1 differentially affect endothelial junction dynamics through their roles in contractility, adhesion turnover, and actin polymerization.

Conserved cysteines in titin sustain the mechanical function of cardiomyocytes

The paper identifies that mutations in conserved titin cysteines disrupt mechanoredox control, leading to dilated cardiomyopathy in humans.

Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially-infected epithelial cells

The paper shows that innate immune signaling triggers mechanical competition, leading to the collective extrusion of infected epithelial cells by uninfected bystanders.

Balance of Mechanical Forces Drives Endothelial Gap Formation and May Facilitate Cancer and Immune-Cell Extravasation

This study shows that mechanical forces drive spontaneous gap formation in endothelial cells, which may facilitate cancer and immune cell extravasation by preferentially occurring at cell vertices.