Y.-T. Yeh

Mapping fibrotic microenvironments: single-cell and spatial profiling of Schistosoma mansoni-induced tissue fibrosis

This study uses single-cell spatial transcriptomics to map fibrotic microenvironments in Schistosoma mansoni-infected mice, revealing organ-specific fibrosis architecture and shared signaling pairs for potential therapeutic targets.

Tunable photoinitiated hydrogel microspheres for direct quantification of cell-generated forces in complex three-dimensional environments

This paper develops tunable hydrogel microspheres for quantifying cell-generated forces in 3D environments using microfluidics and photopolymerization.

A single dose of intravenous human amniotic membrane-derived mesenchymal stem cells limits transmural infarction, reduces fibrosis size, and improves left ventricular systolic function in the myocardial ischemic/reperfusion model of rats

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

Cardiopulmonary bypass activates classical monocytes via shear-mediated activation of Store-Operated Calcium Entry

The paper identifies SPTAN1 and RAF1 as genes activated by shear stress during cardiopulmonary bypass, leading to inflammation and cell death through store-operated calcium entry.

Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation

This study investigates how Schistosoma mansoni eggs interact biomechanically with vascular endothelial cells to facilitate their extravasation from blood vessels.

Cyclic mechanical stresses alter erythrocyte membrane composition and microstructure and trigger macrophage phagocytosis

This study shows cyclic mechanical stress alters erythrocyte membrane composition and microstructure, leading to increased macrophage phagocytosis.

Accurate Virus Identification with Interpretable Raman Signatures by Machine Learning

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

A balance between matrix deformation and the coordination of turning events governs directed neutrophil migration in 3-D matrices

This study shows that neutrophils balance matrix deformation and turning to navigate 3-D collagen matrices, with myosin-II and Arp2/3 playing key roles in this process.

Three-dimensional Monolayer Stress Microscopy

This paper introduces a 3D Monolayer Stress Microscopy method to measure intracellular stresses in cell monolayers, revealing distinct contributions of lateral deformation and bending.

Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment

This study quantifies the biomechanics of schistosome locomotion in different physical environments and identifies key motility parameters that could inform drug development.

Cell surface vimentin is involved in matrix stiffness-dependent infection of endothelial cells by Listeria monocytogenes

This study shows that ECM stiffness affects Listeria monocytogenes infection of endothelial cells via cell surface vimentin and FAK activity.