Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen binding affinity
P. Dosenovic, E. E. Kara, A.-K. Pettersson, A. McGuire, M. Gray, H. Hartweger, E. S. Thientosapol, L. Stamatatos, M. C. Nussenzweig
This study investigates how B cell precursor frequency and antigen binding affinity influence germinal center recruitment and clonal expansion in HIV-1 vaccine development using adoptive transfer experiments.
bioRxiv · Mar 2, 2018Immunology