H. Hartweger

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

This study shows that WNK1-dependent water influx is essential for CD4+ T cell proliferation and T cell-dependent antibody responses.

Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses

B cell-intrinsic requirement for WNK1 kinase in T cell-dependent antibody responses

This study identifies WNK1 kinase as essential for T-dependent antibody responses by regulating B cell migration, adhesion, and activation.

Critical role of WNK1 in MYC-dependent early thymocyte development

This study identifies WNK1 as essential for thymocyte development by regulating ion homeostasis and MYC expression during the transition from double negative to double positive thymocytes.

Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals

The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.

Antigen-specific humoral immune responses by CRISPR/Cas9-edited B cells

CRISPR/Cas9-edited B cells produce broadly neutralizing antibodies against HIV-1 and elicit protective immune responses in vivo.

Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen binding affinity

This study investigates how B cell precursor frequency and antigen binding affinity influence germinal center recruitment and clonal expansion in HIV-1 vaccine development using adoptive transfer experiments.