Chemoproteomics identifies proteoform-selective caspase-2 inhibitors
J. O. Castellon, S. Ofori, E. Armenta, N. Burton, L. M. Boatner, E. E. Takayoshi, M. Faragalla, A. Zhou, K. Tran, J. Shek, T. Yan, H. S. Desai, K. M. Backus
The paper identifies proteoform-selective caspase-2 inhibitors using chemoproteomics, revealing a unique non-catalytic cysteine and validating their selectivity and activity.
bioRxiv · Oct 25, 2023 · PreprintBiochemistry