Author

J. O. Castellon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

K. M. Backus· 2 shared A. Zhou· 1 shared B. F. Cravatt· 1 shared B. Hill-Payne· 1 shared D. W. Wolan· 1 shared E. Armenta· 1 shared E. E. Takayoshi· 1 shared G. E. Gonzalez-Paez· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

K. M. Backus

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 25, 2023

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors

J. O. Castellon, S. Ofori, E. Armenta…·K. M. Backus

The paper identifies proteoform-selective caspase-2 inhibitors using chemoproteomics, revealing a unique non-catalytic cysteine and validating their selectivity and activity.

DOI 10.1101/2023.10.25.563785

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivAug 5, 2019

Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity

J. H. Xu, J. Eberhardt, B. Hill-Payne…·K. M. Backus

The paper uses X-ray crystallography and molecular modeling to study how a small-molecule inhibitor binds to and inhibits procaspase-8, revealing structural changes and key interactions.

DOI 10.1021/acschembio.0c00019

humanprotein structure

𝕏 PostBluesky