Author

K. M. Backus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H. S. Desai· 3 shared L. M. Boatner· 3 shared J. O. Castellon· 2 shared S. Ofori· 2 shared T. Yan· 2 shared A. B. Ball· 1 shared A. C. Turmon· 1 shared A. E. Jones· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

H. S. Desai

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Author profile →

5 papers

Recent·Most cited

Distributable, Metabolic PET Reporting of Tuberculosis

R. M. N. Khan, Y.-M. Ahn, G. A. Marriner, L. E. Via, F. D'Hooge, S. S. Lee, N. Yang, F. Basuli, A. G. White, J. A. Tomko, L. J. Frye, C. A. Scanga, D. M. Weiner, M. L. Sutphen, D. M. Schimel, , B. G. Davis

This paper introduces [18F]FDT, a PET tracer that specifically images Mycobacterium tuberculosis lesions and monitors treatment, enabling global access through a simple synthesis method from [18F]FDG.

Nature Communications · Jun 27, 2024Peer-reviewedBiochemistry

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors

J. O. Castellon, S. Ofori, E. Armenta, N. Burton, L. M. Boatner, E. E. Takayoshi, M. Faragalla, A. Zhou, K. Tran, J. Shek, T. Yan, H. S. Desai, K. M. Backus

The paper identifies proteoform-selective caspase-2 inhibitors using chemoproteomics, revealing a unique non-catalytic cysteine and validating their selectivity and activity.

bioRxiv · Oct 25, 2023 · PreprintBiochemistry

Multi-omic stratification of the missense variant cysteinome

H. S. Desai, S. Ofori, L. M. Boatner, F. Yu, M. Villaneuva, N. Ung, A. Nesvizhskii, K. M. Backus

This paper uses chemoproteogenomics to identify gain-of-cysteine variants in cancer and healthy genomes, revealing their prevalence and potential for drug targeting.

bioRxiv · Aug 12, 2023 · PreprintBiochemistry

Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome

T. Yan, A. R. Julio, M. Villanueva, A. E. Jones, A. B. Ball, L. M. Boatner, A. C. Turmon, S. L. Yen, H. S. Desai, A. S. Divakaruni, K. M. Backus

The paper develops Cys-LoC and Cys-LOx methods to map compartment-specific cysteine oxidation states, revealing novel mitochondrial redox modifications in response to inflammation.

bioRxiv · Jan 22, 2023Biochemistry

Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity

J. H. Xu, J. Eberhardt, B. Hill-Payne, G. E. Gonzalez-Paez, J. O. Castellon, B. F. Cravatt, S. Forli, D. W. Wolan, K. M. Backus

The paper uses X-ray crystallography and molecular modeling to study how a small-molecule inhibitor binds to and inhibits procaspase-8, revealing structural changes and key interactions.

bioRxiv · Aug 5, 2019Biochemistry