ACE-2 Blockade & TMPRSS2 Inhibition Mitigate SARS-CoV-2 Severity Following Cigarette Smoke Exposure in Airway Epithelial Cells In Vitro
S. S. Hussain, E. F. Libby, J. E. P. Lever, J. L. Tipper, S. E. Phillips, M. Mazur, Q. Li, J. Campos-Gomez, K. S. Harrod, S. M. Rowe
This study shows that cigarette smoke increases ACE-2 and TMPRSS2 expression in airway cells, enhancing SARS-CoV-2 infection, which is mitigated by ACE-2 blockade and TMPRSS2 inhibition.
bioRxiv · Jun 23, 2024Cell Biology