K. S. Harrod

Mucociliary Clearance Augmenting Drugs Block SARS-Cov-2 Replication in Human Airway Epithelial Cells

This study tests mucoactive drugs that enhance mucociliary clearance and finds three inhibit SARS-CoV-2 replication in human airway epithelial cells by improving ciliary function and redox state.

Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell model reveals differential host glycoconjugate uptake and metabolism

This study uses ex vivo transcriptomics to show that influenza A virus infection enhances pneumococcal growth and alters bacterial metabolism in human lung epithelial cells.

Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission

This study compares intranasal and intramuscular delivery of a self-amplifying RNA SARS-CoV-2 vaccine, showing that intranasal delivery induces mucosal immunity and reduces viral transmission.

Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection

This study investigates MCT deficiency in Syrian hamsters infected with SARS-CoV-2, finding a 67% reduction in MCT rate by 2 dpi due to decreased motile ciliation.

Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase

This paper identifies water-soluble tocopherol derivatives as potent inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase, showing synergy with remdesivir.

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

Influenza-induced oxidative stress sensitizes lung cells to bacterial toxin-mediated necroptosis

This paper shows that influenza virus increases lung cell sensitivity to bacterial toxin-induced necroptosis through oxidative stress, suggesting necroptosis inhibitors as potential treatments for severe infections.