Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth
R. Tang, E. G. Shuldiner, M. Kelly, C. W. Murray, J. D. Hebert, L. Andrejka, M. K. Tsai, N. W. Hughes, M. I. Parker, H. Cai, Y.-C. Li, G. Wahl, R. Dunbrack, P. K. Jackson, D. Petrov, M. M. Winslow
This study identifies HRAS and NRAS as suppressors of KRASG12D-driven lung cancer using CRISPR screens in mouse models and confirms their role in human cell lines.
bioRxiv · Jul 8, 2021 · PreprintCancer Biology