P. K. Jackson

Filopodial Mechanotransduction is regulated by Angiotensin-Converting Enzyme 2 (ACE2) and by SARS-CoV-2 spike protein

The paper investigates how SARS-CoV-2 spike protein activates calcium and actin dynamics to enable filopodial extension and virus binding through ACE2.

A hierarchical pathway for assembly of the distal appendages that organize primary cilia

The paper identifies a hierarchical pathway for distal appendage assembly, revealing key protein modules and their roles in ciliary formation.

Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages

This study identifies NCS1 as a key protein recruited by CEP89 to the distal appendage, facilitating ciliary vesicle capture and cilium formation.

The IFT81-IFT74 complex enhances GTP hydrolysis to inactivate RabL2 during early steps of intraflagellar transport

This study identifies the IFT81-IFT74 complex as a GTP hydrolysis enhancer for RabL2, crucial for inactivating RabL2 during early intraflagellar transport initiation.

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

This study identifies elevated CD47 in aged muscle stem cells as a marker of dysfunction and shows that targeting CD47 improves regeneration in aged mice.

The Mettl3 epitranscriptomic writer amplifies p53 stress responses

This paper identifies Mettl3 as a p53-interacting protein that stabilizes p53 and enhances its tumor suppressive functions through both protein stabilization and m6A modification of p53 pathway transcripts.

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth

This study identifies HRAS and NRAS as suppressors of KRASG12D-driven lung cancer using CRISPR screens in mouse models and confirms their role in human cell lines.

Divergent molecular signatures of regeneration and fibrosis during wound repair

This study identifies divergent molecular signatures of regeneration and fibrosis during wound repair using multimodal analysis.

Mass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis

The paper reports a proteomics resource analyzing protein expression in mouse adult and aged hematopoietic stem cells and their progenitors, revealing differential expression and gene regulation.

Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models

This study identifies ethacridine, an FDA-approved antiseptic, as a potent inhibitor of SARS-CoV-2 by inactivating viral particles in cellular models.

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

The paper identifies ciliary GPCRs in pancreatic islet cells that regulate insulin and glucagon secretion, with FFAR4 and PTGER4 as key targets for diabetes therapy.

Multiple domains in ARHGAP36 regulate PKA degradation and Gli activation

This study identifies how multiple domains in ARHGAP36 regulate PKA degradation and Gli activation through structural and functional analysis.

Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

The paper identifies new RAS effector pathways and synthetic lethal interactions in lung adenocarcinoma using proteomic and genetic screening.

Ciliation of muscle stem cells is critical to maintain regenerative capacity and is lost during aging

This study identifies ciliary Hedgehog signaling as critical for muscle stem cell regeneration, showing that restoring it in aged mice improves muscle repair.