Author

E. I. Paschalis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Zhou· 6 shared J. Chodosh· 6 shared F. Lei· 5 shared C. H. Dohlman· 4 shared D. G. Vavvas· 3 shared R. Dana· 3 shared D. Vavvas· 2 shared P.-C. Hui· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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6 shared papersImmunology

C. Zhou

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A novel sustained release therapy of combined VEGF and TNF-alpha inhibitors leads to pan-ocular protection for months after severe ocular trauma.

C. Zhou, F. Lei, P.-C. Hui, N. Wolkow, C. Dohlman, D. G. Vavvas, J. Chodosh, E. I. Paschalis

This paper develops a thermosensitive hydrogel DDS for sustained delivery of anti-TNF and anti-VEGF drugs, showing long-term ocular protection after corneal injury.

bioRxiv · Mar 14, 2023 · PreprintPathology

The prophylactic value of TNF-alpha inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma

E. I. Paschalis, C. Zhou, J. Sharma, T. H. Dohlman, S. Kim, F. Lei, J. Chodosh, D. Vavvas, A. Urtti, G. Papaliodis, C. H. Dohlman

This study evaluates the toxicity and efficacy of TNF-alpha inhibitors adalimumab and infliximab in preventing retinal cell apoptosis and optic nerve axon loss in rabbits after corneal injury.

bioRxiv · Oct 6, 2022Pathology

CSF1R inhibition by small molecule affects T-helper cell differentiation independently of microglia depletion

F. Lei, N. Cui, C. Zhou, J. Chodosh, D. D. Vavvas, E. I. Paschalis

This study shows that CSF1R inhibition affects T-helper cell differentiation in CD4+ cells, independent of microglia depletion.

bioRxiv · Dec 21, 2021 · PreprintImmunology

Opposing roles of blood-borne monocytes and tissue-resident macrophages in limbal stem cell damage after ocular injury

C. Zhou, F. Lei, M. Mittermaier, B. Ksander, R. Dana, C. H. Dohlman, D. G. Vavvas, J. Chodosh, E. I. Paschalis

This study shows that limbal stem cell damage after ocular injury is mediated by peripheral monocytes rather than direct chemical injury, with tissue-resident macrophages providing protection.

bioRxiv · Jul 25, 2021Immunology

Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries

E. I. Paschalis, D. Lei, C. Zhou, X. Chen, V. Kapoulea, P.-C. Hui, R. Dana, J. Chodosh, D. Vavvas, C. H. Dohlman

This study shows that microglia regulate neuroglia remodeling in ocular injuries, and their depletion leads to increased inflammation and retinal damage.

bioRxiv · Oct 8, 2018Immunology

Permanent neuroglial remodeling of the retina following infiltration of CSF1R-inhibition resistant peripheral monocytes.

E. I. Paschalis, F. Lei, C. Zhou, V. Kapoulea, R. Dana, J. Chodosh, D. G. Vavvas, C. H. Dohlman

This study shows that peripheral monocytes infiltrate the retina after injury, engraft permanently, resist CSF1R inhibition, and contribute to long-term pro-inflammatory neuroglial remodeling.

bioRxiv · May 14, 2018Immunology